As with mouse KRAS G12D cells, stimulation of PERK autophosphorylation at T982 (p-PERK) by TG treatment was associated with increased p-eIF2α and p-ERK as well as decreased DUSP6 expression in human lung cancer cells with KRAS G12C (H23, H358) but not in cells with WT KRAS (H1299, H1703) (Supplementary Fig. 9). This evidence concerns the gene EIF2AK3 and lung cancer.