EIF2AK3 and lung carcinoma: As with mouse KRAS G12D cells, stimulation of PERK autophosphorylation at T982 (p-PERK) by TG treatment was associated with increased p-eIF2α and p-ERK as well as decreased DUSP6 expression in human lung cancer cells with KRAS G12C (H23, H358) but not in cells with WT KRAS (H1299, H1703) (Supplementary Fig. 9).