The U2AF2 E2/E3 ratio and the expression of the CDCA5 mRNA were also significantly higher in tumors expressing high levels of IWS1 (Supplementary Fig. 12h) and IWS1 expression exhibited a positive correlation with tumor stage, in tumors harboring EGFR but not KRAS mutations (Supplementary Fig. 12i). The gene discussed is IWS1; the disease is neoplasm.