Analysis of the RNA-seq data in the GSE141685 lung adenocarcinoma dataset of primary tumors and brain metastases revealed that the expression of IWS1 and its targets in the IWS1 phosphorylation pathway was higher in the metastatic tumors (Fig. 8g, Supplementary Fig. 12k). The gene discussed is IWS1; the disease is metastatic neoplasm.