Analysis of the RNASeq data in the TCGA-LUAD dataset, which contains information on cancer-associated mutations, confirmed the link between IWS1 expression and metastatic disease, but also showed that IWS1 is upregulated in metastatic tumors with EGFR, but not KRAS mutations (Supplementary Fig. 12m). The gene discussed is KRAS; the disease is cancer.