IWS1 and metastatic neoplasm: Analysis of the RNASeq data in the TCGA-LUAD dataset, which contains information on cancer-associated mutations, confirmed the link between IWS1 expression and metastatic disease, but also showed that IWS1 is upregulated in metastatic tumors with EGFR, but not KRAS mutations (Supplementary Fig. 12m).