An increasing number of studies have shown that the Wnt/β-catenin pathway plays roles in different cancers, and we recapitulated the inappropriate activation of this pathway in gastric cancer, leukaemia and nasopharyngeal carcinoma [30–32], Wnt/β-catenin alterations are prominent in NSCLC, and lncRNA FEZF1-AS1 can facilitate the proliferation, migration and invasion of NSCLC cells by supressing the expression of AXIN1 to decrease the degradation of β-catenin [33]. This evidence concerns the gene FEZF1 and leukemia.