Elevated expression of the CD44 v4-10 isoform, which comprises constant and v4-v10 exons, can respond to HGF and Wnt-mediated signals through interactions between the v6 exon and HGF, thereby promoting tumor cell proliferation by maintaining the stemness of cancer stem cells, a feature that is not exhibited by CD44s [74, 75]. This evidence concerns the gene HGF and cancer.