SRSF1 and colorectal carcinoma: In CRC cells, an imbalance exists between the two isoforms because due to elevated SRSF1 expression, MNK2b is dominant while the MNK2a isoform, which has a MAPK-binding domain, is downregulated, thereby promoting cell growth and reducing cell apoptosis by inhibiting the p38a-MAPK signaling pathway [84].