In parallel, we found that male patients with severe COVID-19 have elevated abundances of B cells (lgG− [lgG non-expressed B cell], p = 4.7 × 10−11 and lgG+ [lgG expressed B cell], p = 1.7 × 10−9) and CD4-T EM (effector memory-like CD4 T cells, p = 1.3 × 10−9) but lower abundances of CD4-T nEM cells (non-effector memory-like CD4 T cells, p = 1.1 × 10−7) and DCs (p = 0.016). This evidence concerns the gene CD4 and COVID-19.