Notably, JUN and NFKB1 were enriched among male-biased genes in the GTEx revealed by chromatin immunoprecipitation sequencing in promoter regions.33 Specifically, JUN and NFKB1 were highly expressed, with a broader distribution in squamous cells of men compared to women with critical COVID-19 (Fig. 3d and Supplementary Fig. 3c). The gene discussed is JUN; the disease is COVID-19.