Tumor growth was suppressed in mice with either CD39-/- or CD73-/- Tregs compared with wild-type mice.56 57 When Tregs undergo apoptosis in the TME, apoptotic Tregs release a large amount of adenosine via ectonucleotidases, resulting in far stronger suppression of antitumor immunity.58 This evidence concerns the gene ENTPD1 and neoplasm.