CD8A and neoplasm: A similar phenotype was also observed in gastric cancers with RHOA Y42 mutation, which is loss-of-function mutation that reduces CXCL10/11 levels through IRF1 suppression.80 In addition, hyperactivation of focal adhesion kinase is correlated with Treg infiltration and CD8+ T cell exclusion through regulating chemokine production, including CCL5 production, by tumor cells.81 82