Instead, they can produce inflammatory cytokines, such as interferon (IFN)-γ and IL-17.23 In the TME of melanoma, non-small cell lung cancer (NSCLC), and gastric cancer, eTregs are heavily infiltrated and account for 20%–60% of CD4 +T cells26. The gene discussed is IL17A; the disease is non-small cell lung carcinoma.