After Kaplan–Meier plot and log-rank test analyses, we found that decreased METTL3 and ALKBH5 mRNA expression levels and increased VIRMA, RBM15B, YTHDF3, YTHDC2, HNRNPA2B1, EIF3A, IGF2BP2, and IGF2BP3 mRNA expression levels were significantly associated with poor DFS/PFS in pancreatic cancer patients (P < 0.05). Here, YTHDF3 is linked to familial pancreatic carcinoma.