Rh Bri2 BRICHOS has emerged as an interesting biopharmaceutical candidate for treating AD, as the domain is a potent inhibitor of Aβ42 amyloid fibril formation and in particular its associated neurotoxicity in vitro, in hippocampal slice preparations ex vivo, and in Drosophila models in vivo [15]. The gene discussed is ITM2B; the disease is Alzheimer disease.