CCN4 and hepatocellular carcinoma: revealed that the WISP1 SNP rs2977530 (AG + GG) was associated with hepatocellular carcinoma development and that WISP1 SNPs rs62514004 (AG + GG) and rs16893344 (CT + TT) were correlated with lower risks of large tumor size, reaching a later clinical stage of hepatocellular carcinoma, in 2018 [16].