WISP1 polymorphisms have been identified in various cancers, including breast cancer [13], urothelial cell carcinoma [14], hepatocellular carcinoma [15], oral squamous cell carcinoma [16], lung cancer [17], and uterine cervical cancer [18], but data are scant as to the involvement of WISP1 polymorphisms in gastric cancer. Here, CCN4 is linked to hepatocellular carcinoma.