EGFR and non-small cell lung carcinoma: Osimertinib, a third-generation TKI designed to target both EGFR sensitizing mutations and T790M, was approved for the first-line treatment of patients with EGFRm advanced NSCLC and for the treatment of EGFR T790M mutation-positive NSCLC patients with progressive disease after prior EGFR TKI therapy [19, 20].