The study of Guldiken and collaborators [44] has tested on female population the possible influence of the polymorphism rs3781719, consisting in T-692 C of CALC A gene, on attack frequency and severity and on the occurrence of aura, finding no significant association with migraine (P = 0.44) and aura (P = 0.52). The gene discussed is MICU1; the disease is migraine disorder.