PRKDC and Fanconi anemia: Importantly, this was not due to an inability to detect changes in cell fitness in Atm KO cells upon gene editing, since genes encoding DNA-PK (Prkdc) and components of the Fanconi anaemia pathway (FA) had a greater impact on cell fitness in Atm KO versus Atm WT mESCs in accordance with existing literature (37,61,62) (Supplementary Figure S2C).