Using a univariable logistic regression, we identified parameters that were significantly related to the occurrence of the secondary endpoint (age, systolic blood pressure, diastolic blood pressure, left ventricular ejection fraction, hypertension, diabetes mellitus, chronic obstructive pulmonary disease, NYHA classification, anaemia, natrium, urea, uric acid, estimated glomerular filtration rate, use of ACE inhibitors/angiotensin II receptor blockers, beta-blockers and higher dose of furosemide; the data are not presented). The gene discussed is ACE; the disease is anemia (phenotype).