Of the 11 obesity-related circulating biomarkers examined in MEC-APS participants, the T allele of rs73449607 was associated with a 1.25-fold increase (Beta = 0.22; P = 1.2x10-4) in geometric mean for sex hormone binding globulin (SHBG) (Table 5). Here, SHBG is linked to obesity due to melanocortin 4 receptor deficiency.