The association between rs73449607 and SHBG seemed to be independent of obesity since the effect estimate and P-value remained similar with (Beta = 0.09; P = 3.8x10-4) and without (Beta = 0.11; P = 3.3x10-5) adjustment for total fat mass. The gene discussed is SHBG; the disease is obesity due to melanocortin 4 receptor deficiency.