In the MEC-APS, two loci were associated significantly with pancreatic fat at the genome-wide level: rs73449607 on chromosome 13q21.2 in an intergenic region between GSX1 (GS Homeobox 1) and PLUTO (PDX1 associated long non-coding RNA, upregulator of transcription) and rs79967607 on 6q14 in intron 1 of the EPM2A gene (Figs 1 and 2, Table 2). Here, PDX1 is linked to autoimmune polyendocrinopathy.