SCARF2 and van den Ende-Gupta syndrome: Despite the fact that cell surface SREC‐II does not interact with known extracellular class F scavenger ligands such as AcLDL and complement C1q, its physiological importance may be inferred from several studies reporting the association between SCARF2 gene mutations and an extremely rare disease called van den Ende–Gupta syndrome (VDEGS) [26, 27, 28].