Among these, CCNA1 and STMN2, which we found to be upregulated in the non-tumor infected patient-derived organoids, were previously identified to be upregulated in HCC (Allain et al., 2016; Chen et al., 2019; Gao et al., 2008; Paradis et al., 2003). The gene discussed is CCNA1; the disease is hepatocellular carcinoma.