Conversely, WNK2, RUSC2, CYP3A4, and RGN, among the significantly downregulated genes in the non-tumor iP organoids, have been described as tumor suppressors downregulated in HCC (Allain et al., 2016; Ashida et al., 2017; Tao et al., 2011; Yamaguchi, 2015). This evidence concerns the gene CYP3A4 and hepatocellular carcinoma.