Non-tumor HBV-infected patient-derived (infected patient [iP]) organoids were expanded in culture (EM) and displayed proliferation rates (Figure 4B and data not shown) and expression of progenitor markers LGR5, KRT7, HNF4α, and Sox9 (Figure 4C) comparable to those of hD organoids. This evidence concerns the gene HNF4A and neoplasm.