Previously, Ym1+ macrophages in the KC animal model have been shown to drive fibrosis during pancreatic cancer development (Liou et al., 2017), and after neutralization of CXCR3, or alternatively neutralization of CXCL10, we observed a correlating increase in fibrosis (Figure 4C,D and Figure 4—figure supplement 1D,E). Here, CALCA is linked to pancreatic neoplasm.