Moreover, an in situ IF-IHC analysis of pancreata of KC mice indicated that inflammatory (F4/80+;pY701-STAT1+) macrophages express CXCR3, while alternatively activated (F4/80+;Ym1+) macrophages do not express this receptor (Figure 2D), which also confirmed above in vitro data. Here, STAT1 is linked to keratoconus.