LEP and Insulin resistance: Novel changes found in vascular tissue after short term CAP exposure include: (a) increased PVAT Lep mRNA but not inflammatory genes; (b) increased PVAT anti‐contractile function and aortic contractility; (c) increased PVAT, aortic, and systemic oxidative stress related to lipid peroxidation and subsequent acrolein formation; (d) induced PVAT insulin resistance; and, (e) prevention of CAP‐induced effects on PVAT and aorta in mice with pulmonary overexpression of ecSOD (ecSOD‐Tg mice).