Recent research unveiled that the benefit of ROF treatment in COPD is related to the inhibition of eosinophils rather than neutrophils,35 despite the pathogenesis of COPD being more closely related to CD8 skewness and neutrophil infiltration,36 suggesting that the subjects enrolled in studies concerned with the clinical efficacy of ROF, might include some patients with overlapping asthma. This evidence concerns the gene CD8A and asthma.