Mossenta et al. proved that N-linked glycosylation at Asn-154 in ZIKV influences viral assembly and infectivity in vitro [24], while Fontes-Garfias and his colleagues demonstrated that E glycosylation was necessary for the ZIKV infection in Ifnar1-/- mice and mosquito hosts but did not significantly affect neurovirulence in newborn mice [25]. This evidence concerns the gene IFNAR1 and Zika virus infectious disease.