Blocking IL-13Rα2 might be a promising target for the IBD therapy, safety data of drugs targeting the IL-13 and IL-4 pathway are reassuring, and there were also a small number of studies that demonstrated protective effects of IL-4 pathway inhibition,IL-4 pathways inhibitionrepressed the proliferation of malignant cells and increased apoptosis in a mouse model of colorectal cancer. This evidence concerns the gene IL4 and colorectal cancer.