The differentially upregulated genes in stroke-induced reactive astrocytes included calcium binding proteins (e.g., S100b), glutamate transporters (e.g., Eaat1) and receptors (e.g., Gria2, Grin2a, Grin2b, and Grm5), potassium channels (e.g., Kcnj10 and Hcn2) and water homeostasis channels (e.g., aquaporin 4) (Rusnakova et al., 2013). Here, AQP4 is linked to stroke disorder.