Hence, RNAi is involved in renal fibrosis by inhibiting the overexpression of related genes, most commonly TGF-β1 (Takabatake et al., 2005) along with its downstream genes, such as CTGF (Ren et al., 2015) and proliferator-activated receptor coactivator-1 alpha (PGC-1α) (Wang et al., 2018) and phosphorylation of Drp1 at serine 616 (p-Drp1S616) (Wang et al., 2020b). This evidence concerns the gene TGFB1 and renal fibrosis.