In return, Hoi et al. (2020) identified that the WNT/β-catenin inhibitor, ICG-001, as well as its derivatives blocked TGF-β-induced phosphorylation of Smad2/3, thus ameliorating renal fibrosis triggered both by TGF-β and by Wnt pathways. The gene discussed is SMAD2; the disease is renal fibrosis.