Our results show a significant increase in the number of cells expressing the cFOS protein in certain areas of the Lis1/sLis1 brain, which mimic those described in postmortem brains of SZ patients and schizophrenia-like phenotype mouse models (Dragunow and Faull, 1990; Abdel-Naby Sayed et al., 2001; Keilhoff et al., 2004). This evidence concerns the gene PAFAH1B1 and schizophrenia.