PAFAH1B1 and schizophrenia: Moreover, variations of LIS1 expression have been reported in the dorsolateral prefrontal cortex of patients with schizophrenia (Lipska et al., 2006) and functional alterations of LIS1 protein interactive complex in brain development are relevant to the pathogenesis of schizophrenia and related psychiatric illness (Bradshaw et al., 2011).