In addition, while mutation in other gene regions of LIS1 have been associated to evident structural brain alterations described as lissencephalic spectrum disorders and associated to cerebral palsy and epilepsy (Pilz et al., 1998; Cardoso et al., 2002), deletion of the first coding exon shows a mild phenotype compatible with the histopathological data in SZ (Dobyns et al., 1993; Tabarés-Seisdedos et al., 2008). This evidence concerns the gene PAFAH1B1 and cerebral palsy.