LIS1 is one of the main genes related to Type I lissencephaly, a serious human brain malformation caused by the abnormal formation of the brain during development, the mildest mutations of which lead to a predisposition to several mental disorders (Dobyns et al., 1993; Reiner et al., 1995; Kato and Dobyns, 2003; Barkovich et al., 2005; Wynshaw-Boris, 2007; Tabarés-Seisdedos et al., 2008). This evidence concerns the gene PAFAH1B1 and mental disorder.