Though many aspects of the physiology and regulation of TRPC6 are still elusive, dysfunction of the TRPC6 channel may trigger a wide range of CNS-related diseases such as epilepsy, autism spectrum disorder (ASD) and Alzheimer’s disease, characterized by cognitive dysfunction (Griesi-Oliveira et al., 2015; Kim and Kang, 2015; Thapak et al., 2020). This evidence concerns the gene TRPC6 and epilepsy.