GSDMD and neoplasm: Figure 2A and Figure S1A). Among them, 11 genes (CASP1, PYCARD, APIP, FOXO3, IL18, GSDMA, GSDMC, CASP4, GSDMB, NLRP1, and NAIP) were downregulated while 9 genes (NLRP9, DHX9, CASP3, NLRC4, AIM2, NLRP3, IL1B, GSDME, and GSDMD) were upregulated in tumor tissues. In addition, 13 genes showed significant associations with OS (Figure 2B).