In addition, compared with the benign tumor group, the absolute values of CD4+ TN [113.40 (76.66–181.41) vs. 172.99 (119.10–272.97), p = 0.0024] and CD4+ TCM (232.94 ± 112.03 vs. 328.92 ± 152.39, p = 0.0056) were significantly reduced in the CRC group. The gene discussed is CD4; the disease is benign neoplasm.