CD274 and brain neoplasm: Grapin et al. irradiated mice with brain tumors with 18 × 2 Gy, 3 × 8 Gy, and 1 × 16.4 Gy which have equal biologically effective dose (BED) values, and injected anti-PD-L1 and anti-T-cell immunoreceptor with immunoglobulin and immunoreceptor tyrosine-based inhibitory motif domains (anti-TIGIT) three times a week, starting on the first day of RT [25].