The common 11 genes included CXCL12, TNFRSF10B, IL1RAP, IL12RB1, IL3RA, CSF2RA, EPOR, TNFSF14, IL18BP, TNFRSF4 and IL2RG. Furthermore, considering the essential functions of CXCL12 in AML, we ultimately decided to study CXCL12 in detail. The gene discussed is CXCL12; the disease is acute myeloid leukemia.