To our knowledge, CXCL12 plays a prominent role in the interaction between AML cells and the BM microenvironment, and the CXCL12/CXCR4-axis is importantly involved in the migration, infiltration and overproliferation of AML cells (Ladikou et al., 2020). This evidence concerns the gene CXCR4 and acute myeloid leukemia.