CXCL12 and acute myeloid leukemia: As previously demonstrated, CXCL12 promoted glycolytic reprogramming in AML cells (Braun et al., 2016) whereas the malignant cells could benefit from aerobic glycometabolism, which endowed them with better capacity for cell proliferation, immune evasion, and chemotherapeutics resistance (Vander Heiden, Cantley & Thompson, 2009).