FLT3 and acute myeloid leukemia: With regard to frequently mutated genes in AML, low CXCL12 expressers were more likely to have FLT3-internal tandem duplications (FLT3-ITD) (P = 0.010) and NPM1 mutations (P = 0.015) and less likely to have mutated TP53 (P = 0.046) than those with high CXCL12 expression.