Although the mechanism by which obesity directly causes hypertension is under investigation, activation of the sympathetic nervous system, the amount of intra-abdominal and intravascular fat, sodium retention leading to an increase in renal reabsorption, and the renin-angiotensin system are considered to have important functions in the pathogenesis of obesity-related hypertension [33]. This evidence concerns the gene REN and obesity due to melanocortin 4 receptor deficiency.