For the heart disease biomarkers detection, in 2019, chemiluminescence immunoassays for simultaneous detection of copeptin, heart-type fatty acid-binding protein (h-FABP), and cardiac troponin I (cTnI) based on magnetic carbon composites and the three-dimensional microfluidic paper-based device were presented by Yang et al. And in the detection, Co2+/N-(aminobutyl)-N-(ethylisoluminol) (ABEI) functionalized magnetic carbon composite (Co2+-ABEI-Fe3O4@ void@C) was used as an interface. This evidence concerns the gene TNNI3 and heart disorder.