In a relatively small study enrolling only 54 COVID-19 cases, Gao et al. found that NT-proBNP levels were independently related with in-hospital mortality in severe COVID-19 cases.9 Moreover, Calvo-Fernández measured NT-proBNP levels in 506 COVID-19 patients and found that NT-proBNP levels were independently related with death or mechanical ventilation in such kind of patients.10 However, COVID-19 patients with HF were not excluded in all of these studies despite the fact that the elevated NT-proBNP levels might have also resulted from an acute HF decompensation. The gene discussed is NPPB; the disease is hydrops fetalis.