PHF1 and diabetes mellitus: Overexpression of PHF1 in MDA-treated groups may correlate with the activation of P53 and apoptotic changes.41 We found that treatment of HUVECs with the combination of Res and MDA returned TRIM27to the minimum level comparable to the control group.42 Based on data, Res down-regulated the expression of numerous genes related to chromatin integrity during the onset of diabetes-related cytopathies.