The putative role of APOA1 -75 G/A and +83 C/T has been studied in various diseases across the globe where prominent diseases that have been complied in this study to highlight the implication and role of this sequence variation include hypertension,24 renal cancer,15 Alzheimer’s disease,22 CAD,13 and all the diseases have shown distinct but varied associations. Here, APOA1 is linked to early-onset autosomal dominant Alzheimer disease.