Among these targets, some targets with high topological parameters were defined as hub genes, including RELA, MMP9, PTGS2, ESR1, EGFR, AR, AKT1, HIF1A, AHR, CYP3A4, ABCG2, and MMP2, obtained by the EH-HCC network. The gene discussed is HIF1A; the disease is hepatocellular carcinoma.