Among these targets, some targets with high topological parameters were defined as hub genes, including RELA, MMP9, PTGS2, ESR1, EGFR, AR, AKT1, HIF1A, AHR, CYP3A4, ABCG2, and MMP2, obtained by the EH-HCC network. The gene discussed is ABCG2; the disease is hepatocellular carcinoma.