Among these targets, some targets with high topological parameters were defined as hub genes, including RELA, MMP9, PTGS2, ESR1, EGFR, AR, AKT1, HIF1A, AHR, CYP3A4, ABCG2, and MMP2, obtained by the EH-HCC network. This evidence concerns the gene ESR1 and hepatocellular carcinoma.