HIF1A and metabolic dysfunction-associated steatotic liver disease: These mechanisms of network pharmacology prediction mainly involve the following aspects: regulation of the PI3K-AKT signaling pathway promotes apoptosis and inhibits abnormal proliferation of HCC cells, downregulation of HIF-1A expression is mediated by activating the HIF-1 signaling pathway, and prevention of HCC is induced by regulating lipid metabolism and inhibiting NAFLD by the cytochrome P450 subfamily.