Resveratrol was proved to inhibit inflammatory responses like enhancing heme oxygenase-1 (HO-1) expression via nuclear factor E2-related factor 2 (NRF2) signaling, which mitigated ligature/lipopolysaccharide- (LPS-) mediated alveolar bone loss in rats in an experimental periodontitis (EP) model as a result [37]. Here, HMOX1 is linked to periodontitis.