EGFR and colonic neoplasm: Another study by Ung et al. indicated a key role of STAT3 in promoting resistance to anti-EGFR treatment and showed that STAT3 activity can be inhibited by the anti-EGFR inhibitors in wild-type K-RAS colon cancer cell lines, suggesting that anti-EGFR therapy combined with STAT3 inhibitors may provide a therapeutic benefit for mCRC patients [151].