Many studies proved the effectiveness of ADSCs in the treatment of liver fibrosis in animal models [117–122], and interestingly, Zhang et al. found that cultivating ADSCs in 3D environment presented higher expression of IGF-1, HGF, and interleukin-6 (IL-6) as compared with 2D environment, leading improvement of liver function after transplanting spheroids to a liver fibrosis mouse model [123]. Here, IGF1 is linked to Hepatic fibrosis.