SERPINH1 and Hepatic fibrosis: BMS 986263 is HSP47 siRNA delivering lipid nanoparticle, which has already been tested for safety in healthy human, and in addition, a phase 1b/2 trial to evaluate safety and tolerability of BMS 986236 in patients with moderate to extensive liver fibrosis was completed in 2016 (NCT01858935 and NCT02227459).