NAFLD/NASH is associated with aberrant metabolism; therefore, numerous novel pharmacological therapies target aberrant metabolism, including free fatty acid production and lipotoxicity, insulin resistance and following lipolysis, extreme accumulation of triglyceride in hepatocytes and following disorder in autophagy and mitochondrial functions, excessive free fatty acids, and oxidative and endoplasmic reticulum stress [27]. The gene discussed is INS; the disease is metabolic dysfunction-associated steatohepatitis.