PVs in the ATM gene have been reported to have an increased predisposition to develop a wide range of cancers including breast, ovarian, pancreatic, colorectal, uterine, gastric, and/or prostate cancers as well as colorectal polyps consistent with our own findings (Supplementary Table 7) (Thompson et al., 2005; Sriramulu et al., 2019). Here, ATM is linked to cancer.