ERBB2 and breast cancer: It was observed that PV detection rates were higher in certain clinically categorized sub groups These include: (1) breast and ovarian cancer (both diagnosed in one patient at any age), 11/49 (22.4%), (2) breast cancer <45 years of age, 38/482 (8%), (3) breast cancer <35 year of age, 20/186 (11%), (4) ovarian cancer at any age, 49/455 (11%), (5) triple negative (ER/PR/HER-2/neu negative) breast cancer, (TNBC), 21/218 (9.6%), (6) breast cancer with pancreatic or prostate at any age, 2/10 (20%).