CD8A and neoplasm: A recent study has shown that viral vectors based on PICV and LCMV can be engineered to deliver tumor-associated antigens, such as the non-oncogenic fusion protein of the HPV16 E6 and E7 genes, in a heterologous prime and boost regimen can effectively induce tumor-specific CTL (CD8+ T cell) responses, eliminate established solid tumors and protect vaccinated mice against tumor re-challenge.