Plasma soluble Angiopoietin-2 concentrations were markedly elevated in corticosteroid resistant ITP patients [median 1,446 (IQR 1,079, 2,391) pg/ml] compared with healthy volunteers [606 (464, 872) pg/ml; p < 0.001] (Figure 1A). Here, ANGPT2 is linked to autoimmune thrombocytopenic purpura.