Some exosomes carrying miRNAs (miR-25-3p, miR-130b-3p, miR-425-5p) derived from CRC cells regulate PTEN by activating PI3K/Akt signaling to induce M2-like TAM polarization, and in turn, TAMs promote CRC metastasis by enhancing EMT and secreting vascular endothelial growth factor (VEGF) (92). This evidence concerns the gene PTEN and colorectal carcinoma.