NLRC4 and colorectal carcinoma: Both nucleotide-binding oligomerization domain (NOD)-like receptor C4 (NLRC4) and NOD-like receptor family pyrin domain containing 3 (NLRP3) are the main components of the inflammasome, which can increase TAM infiltration and IL-1β production, and promote CRC metastasis by regulating the crosstalk between TAMs and CRC cells (115, 116).