With these variables, multivariate analysis was conducted and the result was the following: Combined score = -23.845 * (SDF4 relative expression level) + 0.123 * (APACHE II score) + 0.323*(SOFA score) + 3.183 * (cancer status: 0 for without, 1 for with) + 1.988 * (chronic kidney disease: 0 for without, 1 for with) + 15.789 (Table 2 and Figure 3D). Here, SDF4 is linked to chronic kidney disease.