CXCR5+CD8+ T cells have been identified in multiple settings, including tonsils (10, 19), chronic infections [LCMV (11–13), SIV (35, 36), HIV (11, 37), HBV (17, 38)], cancers [lymphoma (11, 18, 39), colorectal (16, 40), thyroid (41)] and autoimmunity (20, 21, 42). Here, CD8A is linked to Autoimmunity.