MSH2 and cancer: Screening of the cancer somatic mutations database COSMIC, for rs373226409 (G>A) variant in MSH2 identified a single hit with a somatic mutation ID COSV51880288, a male tumor sample P-0003841-T01-IM5 with bladder urothelial carcinoma and an unknown status of MSI, with allele frequency of 0.66 and a FATHMM in-silico model prediction of pathogenicity (score, 0.99) (33).