As perturbations of these pathways have been implicated in the pathogenesis of metabolic diseases including insulin resistance (Dodington et al., 2018; Huang et al., 2018) and skeletal muscle accounts for 70–90% of global insulin-mediated glucose disposal, it is possible the increased local expression of IL-15 in mDKO muscle may improve glucose uptake upon insulin administration. This evidence concerns the gene IL15 and metabolic disease.