IL10 and pancreatic neoplasm: Typically, pancreatic cancer generates an immunosuppressive microenvironment that includes immune suppressive cytokines such as interleukin-10 (IL-10) and transforming growth factor β1 (TGFβ1) and immunosuppressive cells, including regulatory T cells (Tregs) and myeloid-derived suppressor cells (MDSCs), leading to the inhibition of the immune response 130.