LOAd703 has a deleted EIACR2 region to improve tumor selectivity and has an E2F binding site inserted upstream of E1A to control virus replication; in addition, its most critical feature is an insertion of the trimerized, membrane-bound human CD40 ligand (TMZ-CD40L) and the full-length human 4-1BB ligand (4-1BBL) 78-80. The gene discussed is CD40LG; the disease is neoplasm.