Among these positively correlated TSGs and MRGs, adenomatous polyposis coli, chromodomain helicase DNA binding protein 1 and enhancer of zeste homolog 2 were found to be significantly reduced in CS-exposed cells (S10, S20 and S30) and lung cancer cells (A549 and H1299) (Figure S6K-M). The gene discussed is EZH2; the disease is lung carcinoma.