Based on the reported cell markers, we defined the cell clusters as follows: myeloid cells with macrophage markers: IL1B 13 and LYZ 14; plasma cells: IGKC 15 and IGHG2 16; B cells: MS4A1 7 and CD37 17; T cells: CD3D 7 and CD2 18; fibroblasts: COL1A1 19 and LUM 7; ductal cells: CLDN4 20 and CFTR 20; cancer cells: PI3 21; endothelial cells: SPARCL1 22 and CLDN5 23; acinar cells: PRSS1 7 and REG3A 7; and stellate cells: RGS5 7 (Figure 3B and Table S3). The gene discussed is REG3A; the disease is cancer.