FGFR4 and cancer: Although FGF15/19 upon the mitogenic and cytoprotective effects is critical in protection of hepatocyte from lipid-mediated cellular stress and injury 20, the carcinogenetic role of FGF15/19/FGFR4 signaling has been recognized in various cancers, including breast, gastric, lung, prostate, nasopharyngeal carcinoma and liver cancer 23.